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MC4R (Melanocortin-4 Receptor) expressed in the hypothalamus and other CNS regions

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The median patient age was 63 years (range, 2294), 70% of patients had a baseline ECOG PS score of 0, 30% had stage III disease, and 70% had stage IV disease (27% M1a

While DHA and melanotan remain the dominant agents in current use, forskolin and carotenoids offer alternative pathways for pigmentation and photoprotection